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The gameplay involves choosing a pathogen type and evolving it to maximize its infectivity, virulence, and lethality while trying to avoid detection and cure efforts by the world's scientists. Players balance the need to spread their pathogen quickly against the need to keep it lethal and to overcome the immune responses and medical interventions aimed at stopping it.

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Your journey is a constant balancing act. You must evolve your plague to increase its infectivity, severity, and lethality, all while keeping it subtle enough to avoid early detection. Simultaneously, you must react to humanity's efforts to develop a cure. Governments will close borders, airports will shut down, and scientists worldwide will race to create a vaccine. Your decisions must outmaneuver their every move to ensure your plague is unstoppable.